2-aminopyridine derivatives, their use as medicines and pharmaceutical compositions containing them

US6762176B1 · kind B1 · utility

Assignee

• Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS · FR

Inventors

• Pierre-Etienne Chabrier de Lassauniere · Paris, FR
• Serge Auvin · Mauchamps, FR
• Jerry Harnett · Gif-sur-Yvette, FR
• Dominique Pons · Paris, FR
• Gerard Ulibarri · Les Ulis, FR
• Dennis Bigg · Gif-sur-Yvette, FR

Key dates

• Filing date: Mar 8, 2001
• Grant date: Jul 13, 2004
• Expiry date: Mar 8, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/505
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns novel 2-aminopyridine derivatives having an activity inhibiting NO-synthase enzymes producing nitrogen monoxide NO and/or trapping reactive forms of oxygen, the methods for preparing them, pharmaceutical compositions containing them and their therapeutic uses, particularly their use as NO-synthase inhibitors and for trapping reactive forms of oxygen whether selectively or not.