Method for producing 5-(1-piperazinyl)-benzofuran-2-carboxamide by transition metal-catalyzed amination

US6762300B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Andreas Bathe · Darmstadt, DE
• Steffen Emmert · Weiterstadt, DE
• Bernd Helfert · Ober-Ramstadt, DE
• Henning Boettcher · Darmstadt, DE

Key dates

• Filing date: Oct 10, 2002
• Grant date: Jul 13, 2004
• Expiry date: Oct 10, 2022

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process for the preparation of 5-(1-piperazinyl)benzofuran-2-carboxamide in which, as intermediate step, 5-bromosalicylaldehyde or one of its derivatives is reacted in a transition metal-catalysed amination with R2-piperazine, in which R2 is as defined in claim 1.