Patent · US Expired

Use of o-vanillin and o-vanillin/trolox combinations

US6764993B2 · kind B2 · utility

7Cited by
9References
21Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMar 12, 2001
Grant dateJul 20, 2004
Priority date
Expiry dateMar 12, 2021

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61K47/22
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The invention provides methods of protecting solid-state proteins from the effects of ionizing radiation which comprise combining the protein with a radiation-protecting amount of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde; radiation-protecting amounts of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde, and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; or radiation-protecting amounts of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde and isopropanol, prior to exposing the protein to ionizing radiation. The invention further provides radiation-resistant pharmaceutical formulations comprising a protein and a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde; a protein and a combination of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde, and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; or a protein and a combination of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde and isopropanol. The invention still further provides a composition comprising a combination of a methoxysalicylaldehyde derivative, preferably 3-methox…

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.