Magnetic nanoparticles having biochemical activity, method for the production thereof and their use

US6767635B1 · kind B1 · utility

Assignee

• Biomedical Apherese Systeme GmbH · DE

Inventors

• Michael Bahr · Munich, DE
• Dimitri Berkov · Jena, DE
• Norbert Buske · Berlin, DE
• Joachim Clement · Jena, DE
• Peter Görnert · Jena, DE
• Klaus Höffken · Weimar, DE
• Kay-Oliver Kliche · Gräfelfing, DE
• Thomas Kober · Bacharach, DE
• Matthias Schnabelrauch · Jena, DE
• Sebastian Vogt · Jena, DE
• Kerstin Wagner · Jena, DE
• Christian Gansau · Rothenburg/Oberlausitz, DE

Key dates

• Filing date: May 24, 2002
• Grant date: Jul 27, 2004
• Expiry date: May 24, 2022

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2998
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to magnetic nanoparticles, their production, and their use.The object of the invention is to provide nanoparticles capable of specifically forming bonds to intracellular biomacromolecules even in the intracellular region of cells, so that separation is possible by exposure to an exterior magnetic field.This is accomplished by means of magnetic nanoparticles having biochemical activity, consisting of a magnetic core particle and an envelope layer fixed to the core particle, and including a compound of general formula M-S-L-Z (I), the linkage sites between S and L and L and Z having covalently bound functional groups, whereinM represents said magnetic core particle;S represents a biocompatible substrate fixed to M;L represents a linker group; andZ represents a group comprised of nucleic acids, peptides or proteins or derivatives thereof, which group has at least one structure capable of specifically binding to a binding domain of an intracellular biomacromolecule.