Inhibition of angiogenesis by high molecular weight kininogen and peptide analogs thereof
US6767889B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Nov 9, 1999 |
| Grant date | Jul 27, 2004 |
| Priority date | — |
| Expiry date | Nov 9, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/8139
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Two-chain high molecular weight kininogen, and peptide analogs thereof having homology to sites within kininogen domain 5, are potent inhibitors of angiogenesis. The peptides have the formula X1-His-Lys-X-Lys-X2 whereinX is any amino acid,X1 is from zero to twelve amino acids, more preferably from zero to six amino acids, most preferably from zero to three amino acids, andX2 is from zero to twelve amino acids, more preferably from zero to six amino acids, most preferably from zero to three amino acids.X is preferably an amino acid having a nonpolar side chain, or a polar side chain which is uncharged at pH 6.0 to 7.0. X is most preferably Asn, Phe or His. Methods of inhibiting endothelial cell proliferation and angiogenesis are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.