Altered antibodies and their preparation
US6767996B1 · kind B1 · utility
13Cited by
2References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 17, 1993 |
| Grant date | Jul 27, 2004 |
| Priority date | — |
| Expiry date | May 17, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An altered antibody chain is produced in which the CDR's of the variable domain of the chain are derived from a first mammalian species. The framework-encoding regions of DNA encoding the variable domain of the first species are mutated so that the mutated framework-encoding regions encode a framework derived from a second different mammalian species. The or each constant domain of the antibody chain, if present, are also derived from the second mammalian species.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.