Process
US6768005B2 · kind B2 · utility
55Cited by
11References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 20, 2000 |
| Grant date | Jul 27, 2004 |
| Priority date | — |
| Expiry date | Dec 20, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the synthesis of phosphorothioate oligonucleotides is provided which comprises assembling an oligonucleotide bound to a solid support in the presence of acetonitrile; prior to cleaving the oligonucleotide from the solid support removing the acetonitrile; and cleaving the oligonucleotide from the solid support. The process is particularly suited to the large scale synthesis of nucleotides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.