Reagents and methods useful for detecting diseases of the breast

US6770435B1 · kind B1 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Patricia Billing-Medel · Gurnee, US
• Maurice Cohen · Miami, US
• Tracey Colpitts · Round Lake, US
• Paula Friedman · Deerfield, US
• Julian Gordon · Lake Bluff, US
• Edward Granados · Vernon Hills, US
• Steven Hodges · Buffalo Grove, US
• Michael Klass · Libertyville, US
• Jon Kratochvil · Wildwood, US
• John Russell · Pleasant Prairie, US
• Christi P. Scheffel · Mundelein, US
• Stephen D. Stroupe · Libertyville, US

Key dates

• Filing date: Nov 1, 1999
• Grant date: Aug 3, 2004
• Expiry date: Nov 1, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/136
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BU101 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.