Pharmaceutically active compounds and methods of use

US6770668B2 · kind B2 · utility

Inventors

• N. Laxma Reddy · Solon, US
• Michael Maillard · Cambridge, US
• David Berlove · Cambridge, US
• Sharad Magar · Somerville, US
• Graham J. Durant · Welwyn Garden City, GB

Key dates

• Filing date: Dec 17, 2002
• Grant date: Aug 3, 2004
• Expiry date: Dec 17, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-dihydrophenanthridinyl compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.