Crosslinked DNA condesate compositions and gene delivery methods

US6770740B1 · kind B1 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Kevin G. Rice · Ann Arbor, US
• Roger Adami · Bothell, US
• Donald Mckenzie · Ypsilanti, US
• Wendy Turner Collard · Kalamazoo, US
• Kai Kwok · Ann Arbor, US
• Youmie Park · Ann Arbor, US
• Yongsheng Yang · Ann Arbor, US

Key dates

• Filing date: Jul 13, 2000
• Grant date: Aug 3, 2004
• Expiry date: Jul 13, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K48/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are improved compositions and methods for use in gene delivery and expression. A range of surprisingly effective cross-linking agents and peptides are provided, as are peptide-DNA carrier compositions and condensed particles with reduced toxicity and increased stability. Advantageous methods of using such compositions in gene delivery and gene expression are further disclosed, which may be used in combination with biocompatible matrices, carriers and/or targeting agents.