Method of preparing (S)- or (R) -3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid

US6773910B1 · kind B1 · utility

Inventors

• Walter Brieden · Glis, CH
• Andrew Naughton · Gipf-Oberfrick, CH
• Karen Robins · Visp, CH
• Nicholas Shaw · Visp, CH
• Andreas Tinschert · Brig, CH
• Thomas Zimmermann · Schaffhausen, CH

Key dates

• Filing date: Dec 30, 1999
• Grant date: Aug 10, 2004
• Expiry date: Dec 30, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/006
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Described are new micro-organisms and a new enzyme capable of using as sole source of nitrogen the propionic acid amide of formula (VI), in racemate form or as optically active isomers. Described also is a method of preparing (S)- or (R)-3,3,2-trifluoro-2-hydroxy-2-methylpropionic acid of formulas (I) and (II) starting from trifluoroaceto-acetic ester. The first three process steps are chemical, the fourth process step microbiological.