Patent · US Expired

Extracorporeal endotoxin removal method

US6774102B1 · kind B1 · utility

16Cited by

6References

18Claims

0Family size

Assignee

Gambro Dialysatoren GmbH & Co. KG · DE

Inventors

Carl-Martin Bell · Hechingen, DE
Markus Storr · Echterdingen, DE
Werner Beck · Rottenburg am Neckar, DE

Key dates

Filing date	Sep 15, 2000
Grant date	Aug 10, 2004
Priority date	—
Expiry date	May 15, 2021

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61M1/3679
WIPO fieldChemical engineering
WIPO sectorChemistry

Abstract

This invention describes blood treating material having the capacity to selectively remove endotoxin and cytokine inducing substances from blood or plasma by extracorporeal adsorption for therapeutic septic shock treatment. The endotoxin adsorption ligands of the invention are oligopeptides synthesized from amino acids having a pk>7.2 such as arginine, lysine or histidine, using a polycondensation step such that the resultant oligopeptides exhibit a high degree of polydispersity. Also provided are methods and devices using an adsorbent having a polydisperse oligopeptide of the invention immobilized on a solid state support medium for removing endotoxin from the blood of human or animal subject.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.