Pyrrolo[1,2-b][1,2,4]oxadiazine diones useful as nitric oxide synthase inhibitors

US6774126B2 · kind B2 · utility

Assignee

• Pharmacia Corporation · SE

Inventors

• Donald W. Hansen, Jr. · Chicago, US
• E. Ann Hallinan · Evanston, US
• Alok K. Awasthi · Skokie, US
• Suzanne Metz · Chesterfield, US
• Jeffrey A. Scholten · Chesterfield, US
• Jeffery S. Snyder · Manchester, US
• Mihaly V. Toth · Chesterfield, US
• Ronald Keith Webber · Holden, US

Key dates

• Filing date: Oct 7, 2002
• Grant date: Aug 10, 2004
• Expiry date: Oct 7, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pyrrolo[1,2-b][1,2,4]oxadiazine-2,3(6H)-diones having the formula: or pharmaceutically acceptable salts thereof, useful as nitric oxide synthase inhibitors wherein each substituent is defined herein.