Calanolide and related antiviral compounds, compositions, and uses thereof

US6774141B1 · kind B1 · utility

Assignee

• The United States of America, as represented by the Secretary, Health and Human Services · US

Inventors

• Michael R. Boyd · Mobile, US
• John H. Cardellina, II · Fort Detrick, US
• Kirk R. Gustafson · Frederick, US
• James B. McMahon · Frederick, US
• Richard W. Fuller · Fairfield, US
• Gordon M. Cragg · Bethesda, US
• Yoel Kashman · Nes Ziona, IL

Key dates

• Filing date: May 20, 1998
• Grant date: Aug 10, 2004
• Expiry date: May 20, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.