Process for eliminating N-terminal methionine
US6774221B1 · kind B1 · utility
10Cited by
1References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 7, 2001 |
| Grant date | Aug 10, 2004 |
| Priority date | — |
| Expiry date | May 7, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/12
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for removing from a peptide the diketone of the methionine residue, and a method for manufacturing a peptide or salt thereof which does not possess an N-terminal methionine residue, characterized by having a peptide or salt thereof which possesses a diketone of the optionally oxidized N-terminal methionine residue react with 3,4-diaminobenzoic acid or a salt thereof in the presence of acetic acid and sodium formate, formic acid and sodium formate, or formic acid and sodium acetate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.