Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates

US6774243B2 · kind B2 · utility

Assignee

• Agouron Pharmaceuticals, Inc. · US

Inventors

• Qingping Tian · San Diego, US
• Naresh Nayyar · San Diego, US
• Srinivasan Babu · San Diego, US
• Junhua Tao · San Diego, US
• Terence Moran · San Diego, US
• Raymond Dagnino, Jr. · El Cajon, US
• Lennert J. Mitchell, Jr. · Chula Vista, US
• Travis Remarchuk · South San Francisco, US
• Michael Joseph Melnick · Portage, US
• Steven Bender · Oceanside, US

Key dates

• Filing date: Oct 30, 2001
• Grant date: Aug 10, 2004
• Expiry date: Mar 20, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Efficient synthetic routes for the preparation of rhinovirus protease inhibitors of formula I, as well as key intermediates useful in those synthetic routes. These compounds of formula I, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses.