Patent · US Expired

Method of synthesizing 1&agr;-hydroxy-2-methylene-19-nor-homopregnacalciferol

US6774251B2 · kind B2 · utility

8Cited by

14References

15Claims

0Family size

Assignee

Wisconsin Alumni Research Foundation · US

Inventors

Hector F. DeLuca · Deerfield, US
Sumithra Gowlugari · San Mateo, US
Rafal R. Sicinski · Warszawa, PL

Key dates

Filing date	Mar 26, 2003
Grant date	Aug 10, 2004
Priority date	—
Expiry date	Mar 26, 2023

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A method of making 1&agr;-hydroxy-2-methylene-19-nor-homopregnacalciferol. The method includes the steps of condensing a bicyclic ketone with an allylic phosphine oxide to produce a protected 19-nor-pregnacalciferol analog, thereafter cleaving the protecting group to form 22-alcohol, converting the alcohol to an ester, reducing the ester to 17&bgr;-isopropyl-19-nor-vitamin D analog, and finally deprotecting the 17&bgr;-isopropyl derivative to form the desired compound.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.