Bio-reactor and cell culture surface with microgeometric surfaces
US6777227B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Jan 7, 2003 |
| Grant date | Aug 17, 2004 |
| Priority date | — |
| Expiry date | Jan 7, 2023 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L3/5085
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A bioreactor or cell culture surface comprises a multiplicity of microwells appearing, upon enlargement in the range of 200 to 1000 magnifications, as a honeycomb structure consisting of a plurality of rows of irregular hexagons, each having a transverse x-axis, a longitudinal y-axis, and a z-axis which defines a height of each microwell. Co-parallel major bases define the directionality of anticipated cell growth, while pairs of equilateral minor bases define the x-axis width of each microwell. An arrow-like geometry is defined by the equilateral pairs of minor bases which also define an x-axis separation between opposing major bases of the hexagon to induce cell growth directionality. An acute angle exists between the members of the arrow-like pairs of minor bases, while an obtuse angle exists between contiguous major and minor bases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.