Adipose-derived stem cells and lattices

US6777231B1 · kind B1 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Adam J. Katz · Charlottesville, US
• Ramon Llull · Palma, ES
• William J. Futrell · Pittsburgh, US
• Marc H. Hedrick · Encinitas, US
• Prosper Benhaim · Los Angeles, US
• Hermann Peter Lorenz · Stanford, US
• Min Zhu · Shanghai, CN

Key dates

• Filing date: Sep 10, 2001
• Grant date: Aug 17, 2004
• Expiry date: Sep 10, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.