Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives

US6777407B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Annmarie Louise Sabb · Pennington, US
• Robert L. Vogel · Stratford, US
• James A. Nelson · Washington Crossing, US
• Sharon Rosenzweig-Lipson · East Brunswick Township, US
• Gregory S. Welmaker · Jackson, US
• Joan E. Sabalski · Yardville, US

Key dates

• Filing date: Nov 2, 2001
• Grant date: Aug 17, 2004
• Expiry date: May 26, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides compounds of the formulae: wherein:R1 is hydrogen, —C(O)CH3 or alkyl of 1-6 carbon atoms;R2 and R3 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl, alkoxy of 1-6 carbon atoms, —CH2OH, fluoroalkyl, alkyl sulfonamide of 1-6 carbon atoms, alkyl amide of 1-6 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, fluoroalkoxy of 1-6 carbon atoms, acyl of 2-7 carbon atoms, aryl, or aroyl;R4 and R5 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, fluoroalkyl, —CN, alkyl sulfonamide of 1-6 carbon atoms, alkyl amide of 1-6 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, fluoroalkoxy of 1-6 carbon atoms, acyl of 2-7 carbon atoms, or aroyl;R6 and R7 are each independently hydrogen, C1-C6 alkyl or cycloalkyl;or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions containing these compounds and methods for their use, including treatment of obsessive-compulsive disorder, panic disorder, depression, anxiety, generalized anxiety disorder, schizophren…