Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions

US6777423B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Rolf Banholzer · Stuttgart, DE
• Peter Sieger · Mittelbiberach, DE
• Christian Kulinna · Mainz, DE
• Michael Trunk · Ingelheim am Rhein, DE
• Manfred Graulich · Waldalgesheim, DE
• Peter Specht · Ober-Hilbersheim, DE
• Helmut Meissner · Ingelheim am Rhein, DE
• Andreas Mathes · Ockenheim, DE

Key dates

• Filing date: Jan 30, 2003
• Grant date: Aug 17, 2004
• Expiry date: Jan 30, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D451/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Crystalline monohydrate of (1&agr;,2&bgr;,4&bgr;,5&agr;,7&bgr;)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof, and their use.