Diphenyl derivatives

US6777442B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Helmut Haning · Milford, US
• Michael Woltering · Hilden, DE
• Gunter Schmidt · Houghton, US
• Christiane Faeste · Haan, DE
• Hilmar Bischoff · Wuppertal, DE
• Axel Kretschmer · Wuppertal, DE
• Verena Vöhringer · Wuppertal, DE
• Peter Ellinghaus · Melle, DE

Key dates

• Filing date: Feb 26, 2002
• Grant date: Aug 17, 2004
• Expiry date: Feb 26, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of the general formula (I) in which X represents O, S, SO, SO2, CH2, CHF, CF2 or NR8, and Z represents a group of the formula in which A represents O or S, the subscript “a” is 0 or 1, group D represents a straight-chain (C1-C4)-alkylene group, and R36 represents OR37 or NR38R39. It also relates to processes for preparation of such compounds and to their use in medicaments for the treatment of depression, goiter, cancer of the thyroid gland, arteriosclerosis, hypercholesterolaemia, dyslipidaemia, obesity, cardiac insufficiency, pulmonary emphysema, pain, migraine, Alzheimer's disease, osteoporosis, cardiac arrhythmias, hypothyroidism, skin disorders or diabetes.