Patent · US Expired

Polyamide nucleic acid derivatives and agents and processes for preparing them

US6777544B2 · kind B2 · utility

3Cited by

3References

78Claims

0Family size

Assignee

Aventis Pharma Deutschland GmbH · DE

Inventors

Eugen Uhlmann · Königstein, DE
Gerhard Breipohl · Scheinfeld, DE
David William Will · Schwalbach, DE

Key dates

Filing date	Apr 17, 2001
Grant date	Aug 17, 2004
Priority date	—
Expiry date	Apr 17, 2021

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to PNA derivatives which carry, at the N terminus of the PNA backbone, a phosphoryl radical. The phosphoryl radical can be, for example, a phosphate radical, or a substituted phosphoryl radical, with substituted phosphoryl derivatives carrying, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or groups which increase the binding affinity of the PNA derivative for nucleic acids. The invention furthermore relates to a process for preparing the abovementioned PNA derivatives and to their use as pharmaceuticals and diagnostic agents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.