Process for the preparation of sulphonamide-substituted imidazotriazinones

US6777551B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Marc Nowakowski · Wuppertal, DE
• Reinhold Gehring · Wuppertal, DE
• Werner Heilmann · Wuppertal, DE
• Karl-Heinz Wahl · Erkelenz, DE

Key dates

• Filing date: Dec 17, 2001
• Grant date: Aug 17, 2004
• Expiry date: Dec 17, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P15/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.