Preparation of a trans-calanolide ketone intermediate and chiral separation of calanolide alcohols to give racemic calanolide A
US6777562B1 · kind B1 · utility
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7Claims
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Key dates
| Filing date | Feb 19, 2003 |
| Grant date | Aug 17, 2004 |
| Priority date | — |
| Expiry date | Feb 19, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The method of the invention comprises a process for synthesizing a trans-calanolide A ketone intermediate used in the synthesis of racemic trans-calanolide A. The invention further comprises a method for removing a racemic calanolide B diastereomer from a mixture of calanolide A and calanolide B diastereomers formed in the last step of the synthesis of calanolide A by crystallization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.