Pox virus comprising DNA sequences encoding CEA and B7 antigen
US6780407B1 · kind B1 · utility
24Cited by
1References
12Claims
0Family size
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Inventors
Key dates
| Filing date | Sep 15, 2000 |
| Grant date | Aug 24, 2004 |
| Priority date | — |
| Expiry date | Jan 8, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/24122
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Attenutated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of: human tumor necrosis factor; nuclear phosphoprotein p53, wiltype or mutant; human melanoma-associated antigen; IL-2; IFN&ggr;; IL-4; GMCSF; IL-12; B7; erb-B-2 and carcinoembryonic antigen. The recombinant viruses and gene products therefrom are useful for cancer therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.