Reduction of adhesions using controlled delivery of active oxygen inhibitors
US6780427B2 · kind B2 · utility
9Cited by
55References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 27, 1998 |
| Grant date | Aug 24, 2004 |
| Priority date | — |
| Expiry date | Jan 30, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
SOD and other active oxygen inhibitors are directly applied in combination with a barrier material at local sites of tissue injury to prevent or decrease formation of adhesions and undesirable proliferation of cells. Preferred barrier materials are polymeric hydrogels providing controlled release of AOI which are directly applied to the afflicted tissue. Examples demonstrate the effects of SOD on pelvic adhesions in the rat when administered by intraperitoneal (I.P.) bolus and by localized sustained release from a topically applied hydrogel system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.