Unimolecular polymeric micelles with an ionizable inner core
US6780428B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 8, 2001 |
| Grant date | Aug 24, 2004 |
| Priority date | — |
| Expiry date | Jul 3, 2021 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J13/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention describes the preparation of unimolecular polymeric micelles (UPM) that bear a hydrophilic shell and a potentially ionizable and relatively hydrophobic core at a determined pH value. The core becomes electrostatically charged as the pH is changed. Such micelles can be made from either biodegradable or non-biodegradable polymers. Loaded drugs can be physically retained in the micelles when the pH of the surrounding medium favors interactions with the core. Upon a change in pH, modification in the ionization state of the core will decrease the interactions between the drug and the inner core and facilitate the release of the micellar contents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.