Modified factor VIII cDNA and its use for the production of factor VIII
US6780614B2 · kind B2 · utility
9Cited by
3References
10Claims
0Family size
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Key dates
| Filing date | Feb 8, 2002 |
| Grant date | Aug 24, 2004 |
| Priority date | — |
| Expiry date | Feb 8, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A modified Factor VIII cDNA is disclosed wherein the B-domain of the wild type factor cDNA has been deleted and a truncated Factor IX intron 1 has been inserted in two locations of the Factor VIII cDNA and as a promoter a cDNA is used which is suitable for the expression in hematopoietic cell lines and specifically in platelets.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.