Microbial transformation method for the preparation of an epothilone
US6780620B1 · kind B1 · utility
22Cited by
3References
21Claims
0Family size
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Key dates
| Filing date | Dec 21, 1999 |
| Grant date | Aug 24, 2004 |
| Priority date | — |
| Expiry date | Dec 21, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/182
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said alkyl group to a hydroxyalkyl group, and effecting said hydroxylation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.