Antibiotic inducible/repressible genetic construct for gene therapy or gene immunization

US6780639B1 · kind B1 · utility

Assignee

• UNIVERSITÉ LIBRE DE BRUXELLES · BE

Inventors

• Abdelwahed Chtarto · Brussels, BE
• Liliane Tenenbaum · Ittre, BE
• Marc Levivier · Waterloo, BE
• Marc Peschanski · Créteil, FR
• Jacques Brotchi · Brussels, BE
• Thierry Velu · Brussels, BE

Key dates

• Filing date: Aug 24, 2000
• Grant date: Aug 24, 2004
• Expiry date: Aug 24, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/185
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is related to an antibiotic inducible/repressible genetic construct for controlling the transcription of a gene of interes: by a cell. The genetic construct comprises a bi-directional antibiotic controlled activator-responsive promoter/operator sequence which is located between the gene of interest and a cistron encoding a reverse antibiotic controlled transactivator and controls the transcription of the gene of interest and of the cistron.