Linear cyclic ureas

US6780868B2 · kind B2 · utility

Assignee

• LES LABORATOIRES SERVIER · FR

Inventors

• Jean-Louis Peglion · Le Vésinet, FR
• Christophe Poitevin · Paris, FR
• Jean-Paul Vilaine · Châtenay-Malabry, FR
• Nicole Villeneuve · Rueil-Malmaison, FR
• Marie-Pierre Bourguignon · Chatou, FR
• Catherine Thollon · Paris, FR

Key dates

• Filing date: Feb 20, 2003
• Grant date: Aug 24, 2004
• Expiry date: Feb 20, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula (I): wherein:V represents a single bond or a linear or branched (C1-C6)alkylene chain,M represents a single bond or a linear or branched (C1-C6)alkylene chain,A and E each represents nitrogen or CH, but at least one of the two groups A or E represents nitrogen,W represents a group of formula (i): X represents carbonyl,G1 represents a linear C3 alkylene chain optionally containing a double bond and/or being optionally substituted by a hydroxyl group,their isomers, their hydrates, their solvates, and additional salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same which are useful in the treatment of diseases or pathological conditions in which endothelial dysfunction is known.