Method for the synthesis of peptide salts, their use and the pharmaceutical preparations, containing peptide salts

US6780972B2 · kind B2 · utility

Assignee

• Zentaris GmbH · DE

Inventors

• Michael Damm · Rödermark, DE
• Waldemar Salonek · Heidelberg, DE
• Jurgen Engel · Alzenau, DE
• Horst Bauer · Winnenden, DE
• Gabriele Stach · Frankfurt, DE

Key dates

• Filing date: Aug 24, 2001
• Grant date: Aug 24, 2004
• Expiry date: Aug 24, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for producing peptide salts, including reacting an acid addition salt of a basic starting peptide in the presence of a diluent in a mixed bed ion exchanger, with a mixture of an acid and a basic ion exchanger during the formation of a free basic peptide, and then separating the ion exchanger and then the free basic peptide, with an inorganic or organic acid, and then forming the desired acid addition salt of the peptide, and removing the diluent.