Process for the preparation of 7-substituted-3 quinolinecarbonitriles

US6780996B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Diane Boschelli · New City, US
• Yanong Wang · Hackettstown, US
• Steve Lawrence Johnson · Buffalo, US
• Dan Maarten Berger · New City, US

Key dates

• Filing date: Apr 29, 2003
• Grant date: Aug 24, 2004
• Expiry date: Apr 29, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There is provided a process for the preparation of 7-substituted-3-quinolinecarbonitriles and intermediates useful in a process to prepare 7-substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile is converted in three steps to 7-substituted-3-quinolinecarbonitriles which inhibit the action of certain protein kinases and are useful in the treatment of cancer.