Polyepitopic proteinic fragments of the E6 and E7 HPV proteins, production and use thereof in vaccines
US6783763B1 · kind B1 · utility
14Cited by
2References
4Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Apr 29, 2002 |
| Grant date | Aug 31, 2004 |
| Priority date | — |
| Expiry date | Apr 29, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16322
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polyepitopic fragments of the E6 or E7 protein of HPV comprise a peptide sequence of about 15 to 30 amino acids. This peptide sequence contains amino acid sequences of at least 3 different epitopes binding stably to HLA molecules of identical or different type, when these epitopes are obtained by enzymatic degradation of the peptide sequence, particularly in the proteasome, such that at least 4 HLA molecules of different types bind to these epitopes. These 4 HLA molecules are selected from among those of types A1, A2, A3, A11, A24, A29, B7, B8, B18, B27, B35, B44, B51 and B62.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.