Patent · US Expired

Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function

US6784157B2 · kind B2 · utility

26Cited by

0References

6Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Thanos Halazonetis · Philadelphia, US
Wolfgang Hartwig · Wuppertal, DE

Key dates

Filing date	Apr 11, 2001
Grant date	Aug 31, 2004
Priority date	—
Expiry date	Dec 7, 2021

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K14/82
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and to select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.