Modifications of the VEGF Receptor-2 Protein and methods of use
US6784285B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 18, 2000 |
| Grant date | Aug 31, 2004 |
| Priority date | — |
| Expiry date | Feb 18, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A90/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A 2.4 å crystal structure of a protein construct containing the catalytic kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2/KDR), a key enzyme in angiogenesis, has been determined in an unliganded, phosphorylated state. This protein construct, contains a modified catalytic linker and has comparable in vitro kinase activity to constructs containing the entire KID. The resulting construct retains comparable in vitro kinase activity to that of the wild-type KID, and more importantly, allows complete crystallization of the protein such that it may be characterized by X-ray crystallography. The present invention further discloses the use of x-ray crystallographic data for identification and construction of possible therapeutic compounds in the treatment of various disease conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.