Combined chemo-immunotherapy with liposomal drugs and cytokines
US6787132B1 · kind B1 · utility
69Cited by
8References
20Claims
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Key dates
| Filing date | Aug 3, 2000 |
| Grant date | Sep 7, 2004 |
| Priority date | — |
| Expiry date | Aug 3, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/2013
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of antitumor therapy is described in which administration of a chemotherapeutic drug, encapsulated in liposomes, is supplemented by administration of an immunostimulating cytokine. The cytokine is preferably also encapsulated in liposomes. In tumor models for lung and colon carcinomas, this method produced a significantly greater therapeutic effect, as evidenced by survival rate and tumor size, than a combination of the effects produced by the free or liposome-encapsulated components administered individually.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.