Using purified telomerase to identify telomerase activators and inhibitors

US6787133B2 · kind B2 · utility

Assignee

• Geron Corporation · US

Inventors

• Scott L. Weinrich · San Francisco, US
• Edward M. Atkinson, III · Seattle, US
• Serge Lichtsteiner · Cupertino, US
• Alain P. Vasserot · South San Francisco, US
• Ronald A. Pruzan · Palo Alto, US

Key dates

• Filing date: Dec 24, 2002
• Grant date: Sep 7, 2004
• Expiry date: Dec 24, 2022

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/935
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.