Assay for evaluating the therapeutic effectiveness of agents in reducing Alzheimer's disease pathology
US6787318B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 1, 2000 |
| Grant date | Sep 7, 2004 |
| Priority date | — |
| Expiry date | Jun 1, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/975
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
There is provided an assay method for determining the effect of an agent on Alzheimer's Disease pathology by treating microglial cells with A&bgr; peptides, adding CD40 ligand to the microglial cells, adding a therapeutic agent to the microglial cells, and measuring Alzheimer's Disease pathology. Also provided is a method of determining therapeutic effectiveness of an agent for Alzheimer's Disease by measuring the inhibition of CD40-CD40L binding in the presence of the agent. An assay for determining the effect of an agent on Alzheimer's Disease pathology having A&bgr; peptides for adding to microglial cells, CD40 ligand for being added to the microglial cells, a therapeutic agent being added to the microglial cells and a measuring device for reassuring Alzheimer's Disease pathology is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.