Adenovirus carrying gag gene HIV vaccine

US6787351B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Ling Chen · Shanghai, CN
• John Shiver · Doylestown, US
• Andrew J. Bett · Lansdale, US
• Danilo Casimiro · Harleysville, US
• Michael Caulfield · Fort Washington, US
• Michael Chastain · Glenside, US
• Emilio Emini · Paoli, US

Key dates

• Filing date: Mar 27, 2001
• Grant date: Sep 7, 2004
• Expiry date: Mar 27, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16134
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An adenoviral vector is described which carries a codon-optimized gag gene, along with a heterologous promoter and transcription terminator. This viral vaccine can effectively prevent HIV infection when administered to humans either alone or as part of a prime and boost regime also with a vaccine plasmid.