Antibacterial agents

US6787522B2 · kind B2 · utility

Assignee

• British Biotech Pharmaceuticals Ltd. · GB

Inventors

• Michael George Hunter · Felton, GB
• Raymond Paul Beckett · Cowley, GB
• John Martin Clements · Felton, GB
• Mark Whittaker · Felton, GB
• Stephen John Davies · Leander, US
• Lisa Marie Pratt · Cowley, GB
• Zoe Marie Spavold · Felton, GB
• Steven Launchbury · Cowley, GB

Key dates

• Filing date: Apr 30, 2002
• Grant date: Sep 7, 2004
• Expiry date: Apr 30, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I) are antibacterials: wherein:R1 represents hydrogen, or C1-C6 alkyl or C1-C6 alkyl substituted by one or more halogen atoms; R2 represents a group R10—(X)n—(ALK)m— wherein R10 represents hydrogen, or a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, aryl, or heterocyclyl group, any of which may be unsubstituted or substituted by (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, mercapto, (C1-C6)alkylthio, amino, halo (including fluoro, chloro, bromo and iodo), trifluoromethyl, cyano, nitro, —COOH, —CONH2, —COORA, —NHCORA, —CONHRA, —NHRA, —NRARB, or —CONRARB wherein RA and RB are independently a (C1-C6)alkyl group, and ALK represents a straight or branched divalent C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radical, and may be interrupted by one or more non-adjacent —NH—, —O— or —S— linkages, X represents —NH—, —O— or —S—, and m and n are independently 0 or 1; and A represents a group as defined in the specification.