Indole derivatives with 5HT6 receptor affinity

US6787535B2 · kind B2 · utility

Assignee

• Syntex (U.S.A.) LLC · US

Inventors

• Colin C. Beard · Saratoga, US
• Robin Clark · Palo Alto, US
• Lawrence Emerson Fisher · Mountain View, US
• Ralph New Harris, III · Redwood City, US
• David Bruce Repke · Palo Alto, US
• David Putman · Irvine, US

Key dates

• Filing date: Jun 6, 2002
• Grant date: Sep 7, 2004
• Expiry date: Jul 4, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein one of R5, R6 or R7 is a group of general Formula B, wherein W is a —CH— group or a nitrogen atom, and the other substituents are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.