Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-&ggr; binding agents

US6787651B2 · kind B2 · utility

Assignee

• SmithKline Beecham Limited · US

Inventors

• Andreas Stolle · Wuppertal, DE
• Jacques Dumas · Neuilly-Plaisance, FR
• William CARLEY · Village of La Jolla, US
• Philip Coish · New Haven, US
• Steven R. Magnuson · South San Francisco, US
• Yamin Wang · Hubei, CN
• Dhanapalan Nagarathnam · Bethany, US
• Derek Lowe · Scotch Plains, US
• Ning Su · Hamden, US
• William Bullock · Easton, US
• Ann-Marie Campbell · Monroe, US
• Ning Qi · Somerville, US
• Jeremy Lee Baryza · Mountain View, US
• James H. Cook, II · East Hampton, US

Key dates

• Filing date: Oct 9, 2001
• Grant date: Sep 7, 2004
• Expiry date: Oct 9, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR-&ggr; mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis.