(E)-styryl sulfone anticancer agents

US6787667B2 · kind B2 · utility

Assignee

• Temple University-Of The Commonwealth System of Higher Education · US

Inventors

• E. Premkumar Reddy · Villanova, US
• M. V. Ramana Reddy · Upper Darby, US

Key dates

• Filing date: Jun 16, 2003
• Grant date: Sep 7, 2004
• Expiry date: Jun 16, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C317/44
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

(E)-styryl benzylsulfones of formula I are useful as anticancer agents: whereinR1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, fluoro, chloro, iodo, bromo, C1-C6 alkyl, C1-C4 alkoxy, nitro, cyano and trifluoromethyl,with the proviso that(a) R1, R2 , and R3 not all hydrogen when R4 is 2-chloro or 4-chloro;(b) when R1 and R3 are hydrogen and R2 is 4-bromo or 4-chloro, then R4 may not be 4-chloro, 4-fluoro or 4-bromo;(c) when R1 and R3 are hydrogen and R2 is 4-fluoro, then R4 may not be 4-fluoro or 4-bromo,(d) when R1 is hydrogen, and R4 is 2-fluoro, the R2 and R3 may not be 4-fluoro; and(e) when R1 is hydrogen and R3 is 4-hydrogen, 4-chloro, 4-bromo, 4-methyl or 4-methoxy, and R4 is 2-hydrogen, 2-chloro, or 2-fluoro; then R2 may not be 4-hydrogen, 4-chloro, 4-fluoro, or 4-bromo.