Flow cell system for solubility testing
US6788409B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 3, 2002 |
| Grant date | Sep 7, 2004 |
| Priority date | — |
| Expiry date | Sep 3, 2022 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2015/1486
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides a flow cell system for high throughput solubility testing of compounds that is particularly useful for screening large compound collections, such as combinatorial chemical libraries or other such synthetic chemical libraries. The system includes a flow cell to channel a fluid sheath which itself channels a continuous or intermittent sample liquid stream containing a compound for testing. Where the concentration of compound in the sample exceeds the solubility limit, particles of the test compound precipitate. These particles scatter the light from an interrogating light beam directed at the sample liquid stream. Individual flashes of scattered light are detected as electronic pulse signals from the detector and their intensity analyzed according to intensity and number of events. System software analyzes the stored pulse signal data in real-time to determine whether there is a significant increase in scattering over the highly variable background scattering. The software then outputs a signal to effectuate selection of a subsequent sample, which may be a higher concentration sample of the same compound or a sample of a subsequent compound for solubility testi…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.