11&bgr; LONG-CHAIN SUBSTITUTED ESTRATRIENES, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL PREPARATIONS CONTAINING SAID 11&bgr; LONG-CHAIN SUBSTITUTED ESTATRIENES, AND THEIR USE FOR PRODUCING MEDICAMENTS

US6790842B1 · kind B1 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Rolf Bohlmann · Berlin, DE
• Nikolaus Heinrich · Berlin, DE
• Jorg Kroll · Berlin, DE
• Gerhard Sauer · Berlin, DE
• Karl-Heinrich Fritzemeier · Berlin, DE
• Christa Hegele-Hartung · Neheim, DE
• Jens Hoffmann · Mühlenbeck, DE
• Rosemarie Lichtner · Berlin, DE
• Ludwig Zorn · Berlin, DE

Key dates

• Filing date: May 7, 2002
• Grant date: Sep 14, 2004
• Expiry date: May 7, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention describes a 11&bgr;-long-chain-substituted estratriene of general formula (I), in which R11 is a long-chain radical that has a nitrogen atom and optionally a sulfur atom, which in addition can be functionalized in the terminal position with a perfluoroalkyl group or an optionally substituted arly radical. The compound can have antiestrogenic or tissue-selective estrogenic properties and be suitable for the production of pharmaceutical agents.