Purine inhibitors of cyclin dependent kinase 2 & IKBA

US6790958B2 · kind B2 · utility

Inventors

• Robert T. Lum · Palo Alto, US
• Cheri Blum · Alameda, US
• Richard L. Mackman · Millbrae, US
• Michael M. Wick · Sharon, US
• Steven R. Schow · Washingtonville, US
• Jeffery A. Zablocki · Skokie, US
• Prabbha Ibrahim · Palo Alto, US

Key dates

• Filing date: Aug 14, 2001
• Grant date: Sep 14, 2004
• Expiry date: Aug 14, 2021

Classification

• Technology area (CPC G): Physics
• CPC primary: G08G1/163
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the following formula are provided: wherein:R1 is —X—R1′; in which R1′ is alkyl, cycloalkyl, aryl, aralkyl, hetaryl, or heterocyclyl, all of which are optionally substituted;X is —NH;R2 is optionally substituted lower alkyl; andR3 is —NR4R5; in which R4 and R5 independently are hydrogen or lower alkyl optionally substituted by hydroxy or amino; or acid addition salts or cationic salts thereof. The compounds inhibit CDK-2 activity and are useful for treating disorders characterized by undesirable cell proliferation.