Combinatorial dihydrobenzopyran library

US6790965B1 · kind B1 · utility

Assignee

• Pharmacopeia Drug Discovery, Inc. · US

Inventors

• John J. Baldwin · Gwynedd Valley, US
• John Charles Reader · Princeton, US
• Lawrence W. Dillard · Hopewell, US
• Ge Li · Shanghai, CN
• Wenguang Zeng · Lawrenceville, US

Key dates

• Filing date: Sep 8, 1999
• Grant date: Sep 14, 2004
• Expiry date: Sep 8, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B40/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Combinatorial libraries are disclosed which are represented by Formula I:(T′—L)q—Ŝ—C(O)—L′—II′  Iwherein:Ŝ is a solid support; T′—L— is an identifier residue; and —L′—II′ is a ligand/linker residue. These libraries contain dihydrobenzopyrans of the formula: which interact (i.e., as agonists or antagonists) with &agr; adrenergic receptors, dopamine receptors, &dgr;-opiate receptors, and K+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatement of ocular diseases such as glaucoma.