Inhibitors of the ICE/ced-3 family of cysteine proteases
US6790989B2 · kind B2 · utility
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4References
25Claims
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Assignee
Inventors
Key dates
| Filing date | Jul 18, 2001 |
| Grant date | Sep 14, 2004 |
| Priority date | — |
| Expiry date | Aug 1, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0202
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, R, R1, R1′ p and q are as defined herein. The invention is also directed to pharmaceutical compositions containing one or more of these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmnune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.